What are the benefits of cryotherapy?

The strongest evidence for cryotherapy benefits is in exercise recovery and pain management. Multiple studies show that whole-body cryotherapy can reduce delayed-onset muscle soreness (DOMS) by 20-40% compared to passive recovery, accelerate return to baseline performance after intense exercise, and reduce markers of systemic inflammation like IL-6 and C-reactive protein. For chronic pain conditions, several clinical trials report significant pain reduction in rheumatoid arthritis, ankylosing spondylitis, and fibromyalgia patients following multi-session protocols. The proposed mechanisms include vasoconstriction followed by vasodilation (improving circulation), norepinephrine release (which reduces inflammation and pain perception), and endorphin production. Evidence for other commonly marketed benefits is more limited. Weight loss claims are based on the theory that the body burns extra calories rewarming itself, but studies show the caloric expenditure is modest — roughly 50 to 80 additional calories per session. Skin improvement and anti-aging benefits have some preliminary support but lack large-scale clinical trials. Mental health benefits including mood improvement and reduced anxiety have shown promise in small studies, likely driven by the endorphin and norepinephrine response. Always look for providers who are transparent about what the evidence does and does not support for each claimed benefit.

Reviewed by Chad Waldman, Analytical Chemist · Last updated May 2026

About Cryotherapy

Exposure to extreme cold (-110°C to -140°C for 2-3 minutes) triggers peripheral vasoconstriction, norepinephrine release, and cold shock protein activation.