Best Red Light Therapy 2026

[1]Liu M, Meng Y, Ouyang S, Zhai M, Yang L, Yang Y, Wang Y. Neuromodulation technologies improve functional recovery after brain injury: From bench to bedside. — Neural Regen Res, 2026PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[2]Cao Q, Liu Z, Kang H, Wang L. Mechanisms and parameters of photobiomodulation for neurological and neuropsychiatric disorders: whether and how to apply? — Rev Neurosci, 2026PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[3]De Ridder D, Hamblin MR, Vanneste S. Transcranial Photobiomodulation for Neuromodulation of Brain Disorders: A Perspective. — Neuromodulation, 2026PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[4]Ratai EM, Wenke MR, Mercaldo N, Chan ST, Figueiro Longo MG, Welt J, Avesta A, Lee J, Lev MH, Parry BA, Drake L, Anderson RR, Rauch T, Diaz-Arrastia R, Hamblin MR, Vakoc BJ, Gupta R. Low-Level Light Therapy Effect on Metabolites Measured by MR Spectroscopy in Patients with Moderate Traumatic Brain Injury: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. — AJNR Am J Neuroradiol, 2026PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[5]Dos Santos Maciel T, Corrêa Lima Chamy N, Dos Santos Maciel M, Pasqual Marques A. Effect Of Photobiomodulation (Low-Level Laser Therapy) In Patients With Knee Osteoarthritis: A Randomized Controlled Trial. — Lasers Med Sci, 2025PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[6]Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial. — J Affect Disord, 2025PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[7]Stevens AR, Hadis M, Thareja A, Anderson FG, Milward MR, Di Pietro V, Belli A, Palin W, Davies DJ, Ahmed Z. Photobiomodulation improves functional recovery after mild traumatic brain injury. — Bioeng Transl Med, 2025PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[8]Chen G, Xu Z, Ma H, Qin Q, Li X, Yang A, Chen Y, Tan Y, Qiu Y, Wang Y, Ruan H, Jiang X, Zhang J. Transcranial photobiomodulation promotes traumatic brain injury recovery via modulating glial cell polarization and neuroinflammation: a study of 1064 nm light-emitting diodes. — J Transl Med, 2025PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[9]Xue F, Zhou Y. Illuminating eye care: the promise and future of red light therapy in ophthalmology. — Graefes Arch Clin Exp Ophthalmol, 2025PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[10]Díaz L, Gil AC, Marttens AV, Basualdo J, Sotomayor C, Becerra AV, Beltrán V, Jorquera G, Caviedes R, Fernández E. The clinical efficacy of intravascular laser irradiation of blood (ILIB): A narrative review of randomized controlled trial. — Photodiagnosis Photodyn Ther, 2025PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[11]Risbaf Fakour S, Shahraki M, Amirpour Haradasht S, Khazaei AH. Pharmacotherapy versus photobiomodulation therapy in patients with temporomandibular disorders: randomized clinical trial. — Lasers Med Sci, 2025PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[12]Xue K, Zhao Y, Sun S, Li Y, Qi Z. A near-infrared aggregation-induced emission photosensitizer targeting mitochondria for depleting Cu(2+) to trigger light-activated cancer cells oncosis. — Bioorg Chem, 2024PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[13]Xiang J, Yang X, Tan M, Guo J, Ye Y, Deng J, Huang Z, Wang H, Su W, Cheng J, Zheng L, Liu S, Zhong J, Zhao J. NIR-enhanced Pt single atom/g-C(3)N(4) nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression. — Bioact Mater, 2024PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[14]Lawrence J, Sorra K. Photobiomodulation as Medicine: Low-Level Laser Therapy (LLLT) for Acute Tissue Injury or Sport Performance Recovery. — J Funct Morphol Kinesiol, 2024PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[15]Yakout BK, Kamel FR, Khadr MAEA, Heikal LAH, El-Kimary GI. Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial. — BMC Oral Health, 2023PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[16]Yaralı Çevik ZB, Karaman O, Topaloğlu N. Photobiomodulation therapy at red and near-infrared wavelengths for osteogenic differentiation in the scaffold-free microtissues. — J Photochem Photobiol B, 2023PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[17]González-Muñoz A, Cuevas-Cervera M, Pérez-Montilla JJ, Aguilar-Núñez D, Hamed-Hamed D, Aguilar-García M, Pruimboom L, Navarro-Ledesma S. Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review. — Healthcare (Basel), 2023PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[18]Lourinho I, Sousa T, Jardim R, Pinto AC, Iosimuta N. Effects of low-level laser therapy in adults with rheumatoid arthritis: A systematic review and meta-analysis of controlled trials. — PLoS One, 2023PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[19]Chuah JP, Khoo SS, Chung TY, Jayaletchumi G. Photobiomodulation Therapy in Carpal Tunnel Release: A Randomized Controlled Trial. — Photobiomodul Photomed Laser Surg, 2023PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[20]Nizamutdinov D, Ezeudu C, Wu E, Huang JH, Yi SS. Transcranial near-infrared light in treatment of neurodegenerative diseases. — Front Pharmacol, 2022PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[21]Luo WT, Lee CJ, Tam KW, Huang TW. Effects of Low-Level Laser Therapy on Muscular Performance and Soreness Recovery in Athletes: A Meta-analysis of Randomized Controlled Trials. — Sports Health, 2022PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[22]Naterstad IF, Joensen J, Bjordal JM, Couppé C, Lopes-Martins RAB, Stausholm MB. Efficacy of low-level laser therapy in patients with lower extremity tendinopathy or plantar fasciitis: systematic review and meta-analysis of randomised controlled trials. — BMJ Open, 2022PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[23]DE Oliveira MF, Johnson DS, Demchak T, Tomazoni SS, Leal-Junior EC. Low-intensity LASER and LED (photobiomodulation therapy) for pain control of the most common musculoskeletal conditions. — Eur J Phys Rehabil Med, 2022PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[24]Kaynezhad P, Fosbury R, Hogg C, Tachtsidis I, Sivaprasad S, Jeffery G. Near infrared spectroscopy reveals instability in retinal mitochondrial metabolism and haemodynamics with blue light exposure at environmental levels. — J Biophotonics, 2022PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[25]Shinhmar H, Hoh Kam J, Mitrofanis J, Hogg C, Jeffery G. Shifting patterns of cellular energy production (adenosine triphosphate) over the day and key timings for the effect of optical manipulation. — J Biophotonics, 2022PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[26]Maki Y, Kushibiki T, Sano T, Ogawa T, Komai E, Takahashi S, Kitagami E, Serizawa Y, Nagaoka R, Yokomizo S, Ono T, Ishihara M, Miyahira Y, Kashiwagi S, Kawana A, Kimizuka Y. 1270 nm near-infrared light as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines. — Front Immunol, 2022PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[27]Guimarães LS, Costa LDCM, Araujo AC, Nascimento DP, Medeiros FC, Avanzi MA, Leal-Junior ECP, Costa LOP, Tomazoni SS. Photobiomodulation therapy is not better than placebo in patients with chronic nonspecific low back pain: a randomised placebo-controlled trial. — Pain, 2021PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[28]Silva T, Queiroz JR, Turcio KHL, Tobelem DDC, Araújo TR, Coutinho KSL, Chavantes MC, Horliana ACRT, Deana AM, Silva DFTD, Castelo PM, Fernandes KPS, Motta LJ, Mesquita-Ferrari RA, Kalil Bussadori S. Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study. — PLoS One, 2021PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[29]Leyane TS, Jere SW, Houreld NN. Cellular Signalling and Photobiomodulation in Chronic Wound Repair. — Int J Mol Sci, 2021PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[30]York K, Meah N, Bhoyrul B, Sinclair R. A review of the treatment of male pattern hair loss. — Expert Opin Pharmacother, 2020PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[31]Bettleyon J, Kaminski TW. Does Low-Level Laser Therapy Decrease Muscle-Damaging Mediators After Performance in Soccer Athletes Versus Sham Laser Treatment? A Critically Appraised Topic. — J Sport Rehabil, 2020PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[32]Li CF, Chen YJ, Lin TY, Hsiao YH, Fu JC, Chen CH, Lee CL. Immediate responses of multi-focal low level laser therapy on quadriceps in knee osteoarthritis patients. — Kaohsiung J Med Sci, 2019PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[33]Langella LG, Casalechi HL, Tomazoni SS, Johnson DS, Albertini R, Pallotta RC, Marcos RL, de Carvalho PTC, Leal-Junior ECP. Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial. — Lasers Med Sci, 2018PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[34]Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. — J Am Acad Dermatol, 2017PubMed →

Photobiomodulation demonstrates significant therapeutic effects in multiple RCTs

[35]Ferraresi C, Huang YY, Hamblin MR. Photobiomodulation in human muscle tissue: an advantage in sports performance? — J Biophotonics, 2016PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[36]Kim SK, You HR, Kim SH, Yun SJ, Lee SC, Lee JB. Skin photorejuvenation effects of light-emitting diodes (LEDs): a comparative study of yellow and red LEDs in vitro and in vivo. — Clin Exp Dermatol, 2016PubMed →

Red light therapy increases collagen synthesis and improves skin texture

[37]Thunshelle C, Hamblin MR. Transcranial Low-Level Laser (Light) Therapy for Brain Injury. — Photomed Laser Surg, 2016PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[38]Adabbo M, Paolillo FR, Bossini PS, Rodrigues NC, Bagnato VS, Parizotto NA. Effects of Low-Level Laser Therapy Applied Before Treadmill Training on Recovery of Injured Skeletal Muscle in Wistar Rats. — Photomed Laser Surg, 2016PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[39]Leal-Junior EC, Vanin AA, Miranda EF, de Carvalho Pde T, Dal Corso S, Bjordal JM. Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis. — Lasers Med Sci, 2015PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[40]Tsibadze A, Chikvaidze E, Katsitadze A, Kvachadze I, Tskhvediani N, Chikviladze A. [VISIBLE LIGHT AND HUMAN SKIN (REVIEW)]. — Georgian Med News, 2015PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[41]Assis L, Yamashita F, Magri AM, Fernandes KR, Yamauchi L, Renno AC. Effect of low-level laser therapy (808 nm) on skeletal muscle after endurance exercise training in rats. — Braz J Phys Ther, 2015PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[42]de Oliveira AR, Vanin AA, De Marchi T, Antonialli FC, Grandinetti Vdos S, de Paiva PR, Albuquerque Pontes GM, Santos LA, Aleixo Junior Ide O, de Carvalho Pde T, Bjordal JM, Leal-Junior EC. What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial. — Trials, 2014PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[43]Wunsch A, Matuschka K. A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase. — Photomed Laser Surg, 2014PubMed →

Red light therapy increases collagen synthesis and improves skin texture

[44]Quirk BJ, Torbey M, Buchmann E, Verma S, Whelan HT. Near-infrared photobiomodulation in an animal model of traumatic brain injury: improvements at the behavioral and biochemical levels. — Photomed Laser Surg, 2012PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[45]Huang YY, Gupta A, Vecchio D, de Arce VJ, Huang SF, Xuan W, Hamblin MR. Transcranial low level laser (light) therapy for traumatic brain injury. — J Biophotonics, 2012PubMed →

Transcranial photobiomodulation shows neuroprotective effects after TBI

[46]Quirk BJ, Whelan HT. Near-infrared irradiation photobiomodulation: the need for basic science. — Photomed Laser Surg, 2011PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[47]Issa MC, Piñeiro-Maceira J, Vieira MT, Olej B, Mandarim-de-Lacerda CA, Luiz RR, Manela-Azulay M. Photorejuvenation with topical methyl aminolevulinate and red light: a randomized, prospective, clinical, histopathologic, and morphometric study. — Dermatol Surg, 2010PubMed →

Red light therapy increases collagen synthesis and improves skin texture

[48]Helbig D, Moebius A, Simon JC, Paasch U. Nonablative skin rejuvenation devices and the role of heat shock protein 70: results of a human skin explant model. — J Biomed Opt, 2010PubMed →

Red light therapy increases collagen synthesis and improves skin texture

[49]Leal Junior EC, Lopes-Martins RA, Frigo L, De Marchi T, Rossi RP, de Godoi V, Tomazoni SS, Silva DP, Basso M, Filho PL, de Valls Corsetti F, Iversen VV, Bjordal JM. Effects of low-level laser therapy (LLLT) in the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to postexercise recovery. — J Orthop Sports Phys Ther, 2010PubMed →

LLLT pre-exercise reduces fatigue and accelerates post-exercise recovery

[50]Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M. Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. — J Mol Cell Cardiol, 2009PubMed →

Near-infrared light enhances mitochondrial function and ATP production

[51]Canapp DA. Select modalities. — Clin Tech Small Anim Pract, 2007PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[52]Ruiz-Rodriguez R, López-Rodriguez L. Nonablative skin resurfacing: the role of PDT. — J Drugs Dermatol, 2006PubMed →

Red light therapy increases collagen synthesis and improves skin texture

[53]Soriano F, Campana V, Moya M, Gavotto A, Simes J, Soriano M, Soriano R, Spitale L, Palma J. Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results. — Photomed Laser Surg, 2006PubMed →

Red light therapy effectively reduces chronic pain and inflammation markers

[54]Cooper CE, Springett R. Measurement of cytochrome oxidase and mitochondrial energetics by near-infrared spectroscopy. — Philos Trans R Soc Lond B Biol Sci, 1997PubMed →

Near-infrared light enhances mitochondrial function and ATP production