NAD+ IV Therapy Dosage: How Much & How Often
250-1000 mg infused over 2-4 hours; loading series then monthly maintenance. Typical price ~$200-$1,000/infusion; slower drips reduce side effects.
NAD+ IV infusions are commonly given at 250-1000 mg per session, infused slowly over 2-4 hours because faster rates cause discomfort. Protocols vary from a loading series of daily or weekly infusions to monthly maintenance. Prices typically run about $200-$1,000 per infusion. High-quality outcome evidence in healthy adults is limited.
Reviewed by Chad Waldman, Analytical Chemist · Last reviewed 2026-07-15
Dose by goal
| Goal | Dose | Frequency | Evidence |
|---|---|---|---|
| Loading series | 250-500 mg, slow IV | Daily-weekly for a short series | emerging |
| Maintenance | 500-1000 mg | Monthly | limited |
| Typical cost | $200-$1,000 per infusion | Per session | moderate |
NAD+ IV Therapy dose calculator
Estimates based on published protocol ranges — not medical advice.
Session length
120-240 min
Frequency
3-7x/wk
Temp guide
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NAD+ infusions must run slowly (2-4 hours) — rapid infusion commonly causes chest tightness, nausea and flushing. Dosing should be set by the administering clinician. Session minutes here reflect infusion time, not a prescription.
What the evidence shows
- Pharmacokinetic work shows IV NAD+ is measurable in circulation and metabolized to NAD+ pathway products (PMID 31572171).
- Reviews describe NAD+ metabolism and rationale being studied for aging and metabolic endpoints (PMID 26785480).
What it does not show
- Controlled outcome trials of IV NAD+ in healthy adults are scarce; marketed benefits outpace the evidence.
- Infusion 'dose' and frequency are not standardized across clinics, and pricing varies widely by market.
Safety & cautions
- Rapid infusion causes chest pressure, nausea and cramping — rate matters.
- Not evaluated for pregnancy; clear with a clinician if you have cardiovascular or liver conditions.
- IV therapy carries infection and infiltration risks and should be clinician-administered.
Research citations
- Grant R, Berg J, Mestayer R, Braidy N, Bennett J, Broom S (2019). A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging Neuroscience. PMID 31572171Measured circulating NAD+ and metabolites during and after slow IV NAD+ infusion in humans.
- Verdin E (2015). NAD+ in aging, metabolism, and neurodegeneration. Science. PMID 26785480Reviews NAD+ biology underpinning interest in NAD-boosting interventions.
Educational information only — not medical advice. Talk to a licensed clinician before starting any protocol.